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KMID : 0377519840090030353
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Chung-Ang Journal of Medicine
1984 Volume.9 No. 3 p.353 ~ p.361
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Studies on Gastrin and Somatostatin in Patients with Peptic Ulcer Diseases
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Chi Moo-Young
Kim Chong-Sook
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Abstract
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To clarify the interrelationship between the gastrointestinal hormones such as gastrin and somatostatin in gastric acid secretion and the level of gastrin and somatostatin in blood, gastric juice and antral tissues were studied using radioimmunoassay kits in the patients of peptic ulcer diseases(33gastric ulcer cases and 45 duodenal ulcer cases) and 56 normal control. The results were as follows. 1. The patients with gastric ulcer showed significantly higher gastric levels in gastric juice than the normal control group (p＜0.05). Gastrin levels in gastric juice of the gastric ulcer were significantly higher than those of the duodenal ulcer group (p＜0.02). 2. The patients with gastric and duodenal ulcer showed lower plasma somatostatin levels than the normal control group (p＜0.01), and the patients with duodenal ulcer showed higher plasma somatostatin levels than the gastric ulcer group (p＜0.01). 3. The patients with duodenal ulcer showed higher gastric juice somatostatin levels than the normal control group and the gastric ulcer group (p＜0.01), and the antral tissue somatostatin levels of the normal control group were higher than those of the peptic ulcer group. 4. There was close correlation between antral tissue somatostatin and the pH of gastric juice both in the normal control (p＜0.05) and gastric ulcer group (p＜0.05), and correlation between antral tissue gastrin and somatostatin both in gastric ulcer group and in the normal control group (p＜0.05). 5. The ratio of gastrin to somatostatin levels in the same antral tissue of the stomach in patients with gastric ulcer was lower than in the normal control (p＜0.05) and in the duodenal ulcer group (p＜0.05). It was suggested that the levels of gastrin and somatostatin were significantly variable according to the disease conditions because of the differences of seceretory patterns of gastrin and somatostatin.
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KEYWORD
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